Comparison of the effects of pulmonary and extra-pulmonary symptoms on health-related quality of life in patients with severe asthma

Lanario, Joseph W., Hyland, Michael E., Wei, Yinghui, Jones, Rupert C. and Masoli, Matthew (2020) Comparison of the effects of pulmonary and extra-pulmonary symptoms on health-related quality of life in patients with severe asthma. Respiratory Medicine, 162. ISSN 09546111

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Abstract

Objectives To survey the frequency of extra-pulmonary symptoms reported by a sample of patients with severe asthma, their contribution to quality of life and relationship to treatment pathways. Methods Consenting patients (N = 100) attending a severe asthma clinic completed questionnaire measures of extra-pulmonary symptoms (the General symptom Questionnaire, GSQ), pulmonary symptoms (Asthma Control Test, ACT), quality of life (the Severe Asthma Questionnaire, SAQ) and health status (EQ-5D-5L). Results A median of 21 extra-pulmonary symptoms were reported per week. GSQ correlated -0.65 with the ACT and 0.69 with the SAQ. Linear regression showed that both the ACT and GSQ were significant predictors of SAQ mean score, p < 0.001. In patients not receiving biologics, those with high cumulative OCS exposure (≥1120mg per year) had significantly worse scores (p < 0.05) on all questionnaires except the ACT and GSQ compared to those with low cumulative OCS exposure. Discussion Extra-pulmonary symptoms were common in this sample of people with severe asthma. Extra-pulmonary and pulmonary symptoms contribute equal variance to the score of HRQoL, showing that they are equally important contributors to patients’ experience of severe asthma. Extra-pulmonary symptoms are often overlooked in clinical medicine and in measures of quality of life. Participants receiving biologic treatments had lower extra-pulmonary symptoms possibly indicating that biologics reduce systemic symptoms more effectively than other treatments.

Item Type:	Article
Keywords:	severe asthma, quality of life, health measurements, extra-pulmonary symptoms, OCS burden
Depositing User:	Ms Raisa Burton
Date Deposited:	20 Jan 2020 16:24
Last Modified:	10 Jan 2021 04:50
URI:	https://marjon.repository.guildhe.ac.uk/id/eprint/17520
Related URLs:	https://www.res ... 0009-3/fulltext (Publisher URL)

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