Short-term reliability of inflammatory mediators and response to exercise in the heat

Guy, Joshua H., Edwards, Andrew M., Miller, Catherine M., Deakin, Glen B. and Pyne, David B. (2016) Short-term reliability of inflammatory mediators and response to exercise in the heat. Journal of Sports Sciences. ISSN 1466-447X

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Abstract

Prospective application of serum cytokines, lipopolysaccharide, and heat shock proteins requires reliable measurement of these biomarkers that can signify exercise-induced heat stress in hot conditions. To accomplish this, both short-term (seven day) reliability (at rest, n=12) and the acute responsiveness of each biomarker to exercise in the heat (pre and post 60 min cycling, 34.5oC and 70% RH, n=20) were evaluated. Serum was analysed for the concentration of C-reactive protein (CRP), interleukin (IL-6), heat shock protein 72 (eHSP72), immunoglobulin M (IgM) and lipopolysaccharide (LPS). Test-retest reliability was determined as the coefficient of variation (CV). Biomarkers with the least short-term within-subject variation were IL-6 (19%, ± 20%; CV, ± 95% confidence limits) and LPS (23%, ± 13%). Greater variability was observed for IgM, eHSP72 and CRP (CV range 28-38%). IL-6 exhibited the largest increase in response to acute exercise (95%, ± 11%, p = <0.001) and although CRP had a modest CV (12%, ± 7%) it increased substantially post-exercise (p = 0.02, ES; 0.78). In contrast, eHSP72 and LPS exhibited trivial changes post-exercise. It appears variation of common inflammatory markers after exercise in the heat is not always discernible from short-term (weekly) variation.

Item Type: Article
Keywords: Lipopolysaccharide, heat shock proteins, inflammatory cytokines, heat tolerance
Divisions: ?? UniversityCollegePlymouthMarkJohn ??
Depositing User: Dr Theresa Oakley
Date Deposited: 09 Sep 2016 13:04
Last Modified: 14 Feb 2020 15:28
URI: http://marjon.repository.guildhe.ac.uk/id/eprint/10177

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