Current trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survival

Sakkas, Giorgos K., Giannaki, Christoforos D., Karatzaferi, Christina, Maridaki, Maria, Koutedakis, Yiannis, Hadjigeorgiou, Georgios M. and Stefanidis, Ioannis (2014) Current trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survival. Sleep Medicine Reviews, 21. pp. 39-49. ISSN 10870792

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Abstract

Restless legs syndrome (RLS) affects almost one out of three end-stage renal disease patients. This review assesses the current treatment options for uremic RLS and the potential benefits of those treatments on quality of life parameters, cardiovascular mortality and survival. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. Fourteen studies met the inclusion criteria in which the international RLS study group criteria were used as the primary diagnostic tool. Both pharmacological and non-pharmacological approaches were found to reduce the severity of uremic RLS symptoms. Only four studies reported changes on aspects related to quality of life while those changes were also associated with health benefits that resulted in reduced cardiovascular risk. The severity of uremic RLS symptoms can be ameliorated by using dopamine agonists and gabapentin, intravenous iron, exercise or supplementation with vitamins C and E, although some of those treatment benefits may be transient. There is a lack of strong evidence regarding the effects of the pharmacological approaches on quality of life and cardiovascular survival and mortality. In contrast exercise has been proven beneficial in both reducing the RLS symptoms' severity score and improving the quality of life.

Item Type: Article
Keywords: Sleep disorders, Sleep, End-stage renal disease, Hemodialysis, Dopamine agonists, Gabapentin, Exercise training, Periodic limb movements
Divisions: ?? UniversityCollegePlymouthMarkJohn ??
Depositing User: Mrs Wendy Evans
Date Deposited: 14 Feb 2017 20:34
Last Modified: 17 Feb 2020 15:22
URI: http://marjon.repository.guildhe.ac.uk/id/eprint/15304

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