The validation of the Severe Asthma Questionnaire (SAQ)

Hyland, Michael E., Jones, Rupert, Lanario, Joseph and Masoli, Matthew (2018) The validation of the Severe Asthma Questionnaire (SAQ). European Respiratory Journal, 52 (sup62). PA1701. ISSN 1399-3003

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Background: Current disease-specific health related quality of life questionnaires do not assess deficits specific to people living with severe asthma and thus, do not meet the validity criteria set by the USA’s Food and Drug Administration (FDA). The FDA requires a stepwise approach where qualitative research is conducted and documented prior to quantitative research. We describe the final stage of validation for the SAQ. Methods: The Severe Asthma Questionnaire (SAQ), Asthma Control Test (ACT), MiniAQLQ, and EQ-5D-5L were completed by 160 patients attending a severe asthma clinic; 51 patients completed the SAQ on two occasions for test-retest reliability analysis. The SAQ produces two scores, an average of its 16 items and a SAQ-global score from a single 100-point Borg type quality of life scale. Results: Construct validity was demonstrated through factor analysis of the 16 items, convergent validity by correlations of >0.6 between the SAQ and other questionnaires, and discriminant validity by the ability of the SAQ to distinguish between different treatment levels (Figure 1). Test-retest reliability (intra-class correlation) was 0.93 for the SAQ and 0.93 for the SAQ-global. Conclusions: The SAQ was developed using recommended procedures for scale development, and is a valid patient reported outcome measure for use in severe asthma. The SAQ can be used to gain an insight into patients’ perceptions of the impact of severe asthma and treatment on their lives.

Item Type: Article
Additional Information: Article also available through the publisher link provided
Depositing User: Ms Kerry Kellaway
Date Deposited: 26 Jul 2019 13:57
Last Modified: 26 Jul 2019 13:57
Related URLs: https://erj.ers ... 01.article-info (Publisher URL)

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