COVID-19 vaccination acceptance, safety and side-effects in European patients with severe asthma

Bossios, Apostolos, Bacon, Alison M., Eger, Katrien, Paróczai, Dóra, Schleich, Florence, Hanon, Shane, Sergejeva, Svetlana, Zervas, Eleftherios, Katsoulis, Konstantinos, Aggelopoulou, Christina, Kostikas, Konstantinos, Gaki, Eleni, Rovina, Nikoletta, Csoma, Zsuzsanna, Grisle, Ineta, Bieksiené, Kristina, Palacionyte, Jolita, ten Brinke, Anneke, Hashimoto, Simone, Mihălţan, Florin, Nenasheva, Natalia, Zvezdin, Biljana, Čekerevac, Ivan, Hromiš, Sanja, Ćupurdija, Vojislav, Lazic, Zorica, Chaudhuri, Rekha, Smith, Steven James, Rupani, Hitasha, Haitchi, Hans Michael, Kurukulaaratchy, Ramesh, Fulton, Olivia, Frankemölle, Betty, Howarth, Peter, Porsbjerg, Celeste, Bel, Elisabeth H., Djukanovic, Ratko and Hyland, Michael E. (2023) COVID-19 vaccination acceptance, safety and side-effects in European patients with severe asthma. ERJ Open Research, 9 (6). 00590-2023. ISSN 2312-0541 (In Press)

COVID-19 vaccination, acceptance, safety, and side-effects in European patients with severe asthma.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial.

Download (1MB) | Preview


Background Vaccination is vital for achieving population immunity to SARS-CoV-2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients is largely unclear, especially in patients with asthma. The aim was to investigate the vaccination experience in people with severe asthma. Methods Questionnaires about vaccination beliefs (including the Vaccination Attitudes EXamination (VAX) Scale, a measure of vaccination hesitancy-related beliefs), vaccination side-effects, asthma control and overall safety perceptions following COVID-19 vaccination were sent to patients with severe asthma in 12 European countries between May 2021 and June 2021. Results 660 participants returned completed questionnaires (87.4% response rate). Of these, 88% stated that they had been, or intended to be, vaccinated, 9. 5% were undecided/hesitant, and 3% had refused vaccination. Patients who hesitated or refused vaccination had more negative beliefs towards vaccination. Most patients reported mild (48.2%) or no side effects (43.8%). Patients reporting severe side effects (5.7%) had more negative beliefs. Most patients (88.8%) reported no change in asthma symptoms after vaccination, while 2.4% reported an improvement, 5.3% a slight and 1.2% a considerable deterioration. Almost all vaccinated (98%) patients would recommend vaccination to other severe asthma patients. Conclusions Uptake of vaccination in patients with severe asthma in Europe was high, with a small minority refusing vaccination. Beliefs predicted vaccination behaviour and side effects. Vaccination had little impact on asthma control. Our findings in people with severe asthma support the broad message that COVID-19 vaccination is safe and well tolerated.

Item Type: Article
Depositing User: Ms Raisa Burton
Date Deposited: 17 Jan 2024 14:37
Last Modified: 17 Jan 2024 14:37

Actions (login required)

Edit Item Edit Item