Systemic redox imbalance in Chronic Kidney Disease: a systematic review

Poulianiti, Konstantina P., Kaltsatou, Antonia, Mitrou, Georgia I., Jamurtas, Athanasios Z., Koutedakis, Yiannis, Maridaki, Maria, Stefanidis, Ioannis, Sakkas, Giorgos K. and Karatzaferi, Christina (2016) Systemic redox imbalance in Chronic Kidney Disease: a systematic review. Oxidative Medicine and Cellular Longevity, 2016. ISSN 1942-0900

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Patients with chronic kidney disease (CKD) experience an imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage However, it remains unclear in which stage of renal insufficiency the redox imbalance becomes more profound. The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from pre-dialysis stages 1 to 4, to end-stage 5 and whether the various treatments and dialysis modalities influence the redox balance. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. In total, thirty nine studies met the inclusion criteria and were reviewed. Even from an earlystage, an imbalance in redox status is evident and as the kidney function worsens it becomes more profound. Hemodialysis therapy per se seems to negatively influence the redox status bythe elevation of lipid peroxidation markers, protein carbonylation and impairing erythrocyte antioxidant defense. However other dialysis modalities do not so far appear to confer advantages. Supplementation with antioxidants might assist, and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD

Item Type: Article
Keywords: uremia, oxidative stress, chronic kidney disease, patient care, CVD risk prevention
Divisions: ?? UniversityCollegePlymouthMarkJohn ??
Depositing User: Users 134 not found.
Date Deposited: 22 Jun 2016 19:28
Last Modified: 27 Jul 2020 11:47

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