Comparison of the sensitivity of patient-reported outcomes for detecting the benefit of biologics in severe asthma

Hyland, Michael E., Lanario, Joseph W, Menzies-Gow, Andrew, Mansur, Adel H, Dodd, James W, Fowler, Stephen J, Hayes, Gemma, Jones, Rupert C and Masoli, Matthew (2021) Comparison of the sensitivity of patient-reported outcomes for detecting the benefit of biologics in severe asthma. Chronic Respiratory Disease, 18. ISSN 1479-9731

Preview

Text
Comparison of the sensitivity of patient-reported outcomes for detecting the beneﬁt of biologics in severe asthma.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.
Download (546kB) | Preview

Official URL: https://doi.org/10.1177/14799731211043530

Abstract

Background: The sensitivity ofpatient-reported outcomes (PROs) to detect the effects of treatment change dependson the match between the change in items of the PRO and the change that takes place in a sample of people. The aim of this study is to compare the sensitivity of different PROs in detecting changes following the initiation of biologic treatment in asthma. Methods: Patients starting a biologic treatment as part of clinical care completed the Asthma Control Questionnaire (ACQ-6), the Severe Asthma Questionnaire (SAQ and SAQ-global scores) and the EQ5D (EQ-5D-5L and EQ5D-VAS)atbaseline.TheycompletedtheACQ-6,SAQ,SAQ-globalandaretrospectiveglobalratingofchange(GRoC) scaleatweeks4,8and16andcompletedtheEQ-5D-5LandEQ5D-VASatweek16.TheSAQ-globalandEQ5D-VASdiffer but both are single item 100-point questions. Sensitivity was measured by Cohen’s D effect size at each of the three time points. Results: 110 patients were recruited. Depending on the time of assessment, effect size varied between 0.45 and 0.64fortheSAQ,between0.50and0.77fortheSAQ-global;between0.45and0.69forACQ-6;between0.91and1.22for GRoC; 0.32 for EQ-5D-5L and 0.49 for EQ5D-VAS. Conclusion: The sensitivity to change of a questionnaire varies with the time of measurement. The three asthma-speciﬁc prospective measures (SAQ, SAQ-global and ACQ-6) have similar sensitivitytochange.Thesingle-itemEQ5D-VASwaslesssensitivethantheasthmaspeciﬁcmeasuresandlesssensitivethan the single-item SAQ-global. The EQ-5D-5L was least sensitive.

Item Type:	Article
Additional Information:	This article is Open Access.
Keywords:	Asthma, quality of life, measurement, Severe Asthma Questionnaire, Asthma Control Questionnaire-6, EQ5D
Depositing User:	Ms Raisa Burton
Date Deposited:	14 Dec 2021 15:53
Last Modified:	14 Dec 2021 15:53
URI:	https://marjon.repository.guildhe.ac.uk/id/eprint/17675
Related URLs:	https://journal ... 799731211043530 (Publisher URL)

Actions (login required)

Edit Item